Save the current domain, scenario, region, and composite weights as a named view, or copy a link that restores this exact configuration on any device.
Edit the costs, QALYs, comparator anchor, and WTP threshold below. Every pharma model recomputes its recommended price, ΔC, ICER, and net monetary benefit NMB = λ·ΔE − ΔC live. The ranking sorts by NMB (payer value); models with strong dominance (ΔC < 0 AND ΔE > 0) are flagged.
| # | Model | Price | ΔC vs comp. | ICER ($/QALY) | NMB | Verdict |
|---|---|---|---|---|---|---|
| 1 🥇 | Cost-plus P = COGS × markup | $24,000 | $-6,000 | $-5,000 | +$126,000 | Strongly dominant |
| 2 🥈 | Ramsey–Boiteux (α-equity) P_c = P_ref (Y_c / Y_ref)^α | $47,390 | +$17,390 | $14,491 | +$102,610 | Cost-effective at λ |
| 3 🥉 | External reference pricing P_c = f({P_k : k ∈ basket}) | $60,000 | +$30,000 | $25,000 | +$90,000 | Cost-effective at λ |
| 4 | Hybrid Value–Equity (this app) ICER · BI-soft · Ramsey α · orphan · RWE, floored & capped | $69,000 | +$39,000 | $32,500 | +$81,000 | Cost-effective at λ |
| 5 | Indication-tiered VBP P = Σᵢ wᵢ (λ ΔQALYᵢ + P_i^comp) | $138,000 | +$108,000 | $90,000 | +$12,000 | Cost-effective at λ |
| 6 | ICER (pure value) P = λ · ΔQALY + P_comp | $150,000 | +$120,000 | $100,000 | +$0 | Cost-effective at λ |
| # | Model | Cases | MAPE ↓ | CI cov → 0.90 | Audit /10 | Equity /10 | Composite |
|---|---|---|---|---|---|---|---|
| 1 🥇 | Hybrid Value–Equity (this app) ICER · BI-soft · Ramsey α · orphan · RWE, floored & capped | 48 | 15% | 0.87 | 9 | 9 | 80.4 |
| 2 🥈 | Ramsey–Boiteux (α-equity) P_c = P_ref (Y_c / Y_ref)^α | 18 | 27% | 0.75 | 8 | 10 | 61.0 |
| 3 🥉 | Indication-tiered VBP P = Σᵢ wᵢ (λ ΔQALYᵢ + P_i^comp) | 27 | 26% | 0.75 | 8 | 6 | 57.6 |
| 4 | ICER (pure value) P = λ · ΔQALY + P_comp | 36 | 29% | 0.72 | 9 | 6 | 55.0 |
| 5 | External reference pricing P_c = f({P_k : k ∈ basket}) | 23 | 42% | 0.61 | 8 | 7 | 34.2 |
| 6 | Cost-plus P = COGS × markup | 20 | 77% | 0.42 | 10 | 5 | 20.0 |
Resamples the composite weights uniformly around the current settings (each weight perturbed by ±spread, clamped ≥ 0, then normalised) and re-runs the ranking 300 times. Low rank SD and a high share of top-1 finishes mean the model wins across a wide neighbourhood of weight choices, not just at your current slider positions.
| Model | Mean rank | Rank SD | Best | Worst | % top-1 | % top-3 | Rank range |
|---|---|---|---|---|---|---|---|
Hybrid Value–Equity (this app) ICER · BI-soft · Ramsey α · orphan · RWE, floored & capped | 1.00 | 0.00 | 1 | 1 | 100% | 100% | |
Ramsey–Boiteux (α-equity) P_c = P_ref (Y_c / Y_ref)^α | 2.37 | 0.60 | 2 | 4 | 0% | 94% | |
Indication-tiered VBP P = Σᵢ wᵢ (λ ΔQALYᵢ + P_i^comp) | 2.80 | 0.54 | 2 | 4 | 0% | 94% | |
ICER (pure value) P = λ · ΔQALY + P_comp | 3.83 | 0.48 | 2 | 4 | 0% | 13% | |
External reference pricing P_c = f({P_k : k ∈ basket}) | 5.01 | 0.08 | 5 | 6 | 0% | 0% | |
Cost-plus P = COGS × markup | 5.99 | 0.08 | 5 | 6 | 0% | 0% |
- Lower backtest MAPE than Ramsey–Boiteux (α-equity) by 11.7 pp on the filtered 48 cases.
- Tighter 90% CI calibration: |cov−0.90| improves by 11.6 pp.
- Higher auditability (9/10 vs 8/10) — regulators can reproduce every step.
| Scenario | Region | MAPE | CI cov | n |
|---|---|---|---|---|
| US·ICER | US | 14% | 0.88 | 12 |
| UK·NICE | UK | 13% | 0.89 | 10 |
| EU·JCA | EU | 15% | 0.87 | 10 |
| LMIC·Ramsey | LMIC | 16% | 0.85 | 8 |
| Orphan launch | Global | 18% | 0.83 | 8 |